Glucose-Consuming Microbial Control for Skin

Blood sugar (glucose) is both essential for life and dangerous in excess. Outside the blood, for example in urine or sweat, glucose does not appear to provide any benefit, but instead represents a hazard, increasing the risk of infection or other undesirable effects, such as odor or itch.

glucaBAN is formulated to address the risk of infection, odor, and/or itch caused by excreted glucose that is deposited on the skin. SGLT2 inhibitors, a class of drugs that lower blood glucose by causing it to be excreted in urine, can elevate these risks.¹ Even for patients not treated with SGLT2 inhibitors, high blood glucose levels from diabetes can result in glucose excretion when the glucose level in blood exceeds the ability of the kidneys to reabsorb it completely.

glucaBAN contains glucose oxidase, an enzyme that has many uses in bread-making, brewing and the prevention of food spoilage.

glucaBAN is designed to be used as an aid to control unwanted microbial growth that results in itch or odor. Applied to susceptible body surfaces, such as the underarms, groin, and feet, it can provide a targeted mechanism for addressing excess glucose, as well as a high level of protection against microbial growth.

¹The kidneys act by a default-discard mechanism, in which every day 180 liters of plasma (the fluid part of blood) are discarded, and then only the components desired for retrieval are recovered. In this process, 178 liters of water are reabsorbed, along with 1.6 kg of salt, 180 g of glucose, and nearly all of the amino acids, vitamins and minerals. SGLT2 inhibitors partially block the recovery of glucose, diverting glucose from plasma to urine and thereby reducing glucose levels in the blood.